SARS‐CoV‐2 virulence evolution: Avirulence theory, immunity and trade‐offs

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 17 Jul 2021 France English Publisher:Oxford University Press (OUP)Journal:Journal of Evolutionary Biology, volume 34, pages 1,867-1,877 (issn: 1010-061X, eissn: 1420-9101,

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Authors: Alizon, Samuel; Sofonea, Mircea;

doi: 10.1111/jeb.13896 , 10.5281/zenodo.4675081 , 10.5281/zenodo.4675082

pmid: 34196431

pmc: PMC8447366

SARS‐CoV‐2 virulence evolution: Avirulence theory, immunity and trade‐offs

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Abstract

Abstract The COVID‐19 pandemic has led to a resurgence of the debate on whether host–parasite interactions should evolve towards avirulence. In this review, we first show that SARS‐CoV‐2 virulence is evolving, before explaining why some expect the mortality caused by the epidemic to converge towards that of human seasonal alphacoronaviruses. Leaning on existing theory, we then include viral evolution into the picture and discuss hypotheses explaining why the virulence has increased since the beginning of the pandemic. Finally, we mention some potential scenarios for the future.

Country

France

Related Organizations

Université de Montpellier
France
Université de Montpelleir
France
Centre national de la recherche scientifique
France
UNIVERSITE DE MONTPELLIER
France
UNIVERSITE DE MONTPELLIER
France

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Keywords

[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Virulence, SARS-CoV-2, immune escape, COVID-19, virus, maladaptation, Host-Parasite Interactions, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, genomics, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SDV.GEN.GPO] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], immunopathology, Humans, epidemiology, Pandemics, virulence, evolution, SARS-CoV-2, virus, trade-off, immunopathology, genomics, trade-off

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