AbstractBackgroundThe tremendous increase in the use of drugs has considerably increased their side effects.ObjectivesThe aim of this work is to demonstrate Dress syndrome induced by levetiracetam an anti‐epileptic drug.MethodsWe describe a skin eruption observed in an‐hospitalized in an intensive care unit patient who received levetiracetam.ResultsAccording to morphology of the rash and the laboratory findings the rash fulfills the criteria for Dress syndrome.ConclusionLevetiracetam may induce Dress syndrome.