TopicEvidence‐based treatment of non‐suicidal self‐injury (NSSI) in adolescents.PurposeTo review the evidence base supporting current interventions for NSSI.Sources UsedPubMed searches and ancestry analysis.ConclusionsAll treatments studied—developmental group therapy, individual cognitive‐behavioral therapy, and dialectical behavioral therapy for adolescents—were found to be comparable to the typical treatments offered in the treatment settings where the research was conducted. Additional strategies such as harm reduction have very limited evidence suggesting they may be helpful. A few common interventions including relaxation techniques have extremely limited evidence suggesting they may be perceived as harmful by clients.