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TRANEXAMIC ACID AND CORNEAL DETURGESCENCE

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1979 English Publisher:WileyJournal:Acta Ophthalmologica, volume 57, pages 252-257 (issn: 1755-375X, eissn: 1755-3768,

Authors: James G. Buyer; Keith Green; David S. Hull;

doi: 10.1111/j.1755-3768.1979.tb00489.x

pmid: 452885

TRANEXAMIC ACID AND CORNEAL DETURGESCENCE

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Abstract

Recent work has demonstrated decreased corneal thickness in patients with Fuch's dystrophy and in patients following cataract extraction who were given systemic tranexamic acid. Although tranexamic acid is a known antifibrinolytic drug its mechanism in reducing corneal thickness is not known. This experiment demonstrated no increase in the rate of corneal deturgescence of swollen rabbit corneas in the specular microscope when they were perfused for three h with 1 mM or 10 mu tranexamic acid. Pre‐treatment cf rabbits with intravenous tranexamic acid for three days and subsequent perfusion of corneas with tranexamic acid 10 mM also did not increase the rate of corneal deturgescence when compared with controls.

Related Organizations

Georgia Regents University
United States

Keywords

Male, Sucrose, Cyclohexanecarboxylic Acids, In Vitro Techniques, Cornea, Perfusion, Tranexamic Acid, Injections, Intravenous, Animals, Edema, Female, Rabbits

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average