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G‐protein‐coupled receptors and melanoma

descriptionPublicationkeyboard_double_arrow_right Article 11 Jul 2008Publisher:WileyJournal:Pigment Cell & Melanoma Research, volume 21, pages 415-428 (issn: 1755-1471, eissn: 1755-148X,

Authors: Hwa Jin Lee; Brian A. Wall; Suzie Chen;

doi: 10.1111/j.1755-148x.2008.00478.x

pmid: 18582227

pmc: PMC2843908

G‐protein‐coupled receptors and melanoma

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Abstract

SummaryG‐protein‐coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over‐expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and others may play a critical role in tumor invasion and metastasis. Currently, >50% of drug targets to various human diseases are based on GPCR. In this review, the relationships between several GPCR and melanoma development and/or progression will be discussed. Finally, the possibility of using one or more of these GPCR as therapeutic targets in melanoma will be summarized.

Related Organizations

Rutgers, The State University of New Jersey
United States

Keywords

Receptors, Endothelin, Oncogenes, Platelet Membrane Glycoproteins, Receptors, Metabotropic Glutamate, Frizzled Receptors, Receptors, G-Protein-Coupled, Animals, Humans, Receptor, PAR-1, Receptors, Chemokine, Melanoma, Receptor, Melanocortin, Type 1

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	48
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%