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Immunosuppression by Discodermolide

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1993 United States Publisher:WileyJournal:Annals of the New York Academy of Sciences, volume 696, pages 94-107 (issn: 0077-8923, eissn: 1749-6632,

Authors: Longley, R. E.; Gunasekera, S. P.; Faherty, D.; McLane, J.; Dumont, F.;

doi: 10.1111/j.1749-6632.1993.tb17145.x

pmid: 8109858

Immunosuppression by Discodermolide

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Abstract

In summary, discodermolide, a novel, marine-derived compound, is a potent in vitro and in vivo immunosuppressive agent. Discodermolide blocks cellular proliferation in lymphoid and nonlymphoid cells. This blocking action is not due to cytotoxicity. Blockage of cell proliferation by discodermolide appears to occur at the G2/M interface of the cell cycle, similar to that observed with other types of antiproliferative drugs (i.e., doxorubicin). The cell cycle block appears to be reversible, as cells recover normal cycling patterns within 48 h after removal of the compound. Additional work with this compound is targeted towards determining the exact nature of discodermolide's mitotic block and is currently under way.

Country

United States

Related Organizations

Florida Atlantic University
United States
Harbor Branch Oceanographic Institute
United States
Roche (Switzerland)
Switzerland
Florida Southern College
United States
Merck & Co.
United States

Keywords

Cell Cycle, Lymphocyte Activation, Immunosuppressive agents--Mechanism of action, Cell Line, Lactones, Mice, Doxorubicin, Pyrones, Polyketides, Alkanes, Animals, Humans, Carbamates, Immunosuppression, Immunosuppressive Agents

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	57
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average