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EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*

Name: EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*
Keywords: Male, Narcotics, Dextroamphetamine, Diazepam, Ethanol, Morphine, Naloxone, Narcotic Antagonists, Methadyl Acetate, Haplorhini

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1976Publisher:WileyJournal:Annals of the New York Academy of Sciences, volume 281, pages 331-335 (issn: 0077-8923, eissn: 1749-6632,

Authors: C. A. Robinson; M. J. Brocco; K. F. Killam;

doi: 10.1111/j.1749-6632.1976.tb27943.x

pmid: 828467

EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*

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Abstract

Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake. Methadone and L-alpha-acetylmethadol (LAAM) initially reduced, then increased, the morphine intake. Multiple interactions were studied using ethanol, seconal, diazepam, amphetamine, and diphenylhydantoin.

Related Organizations

University of California, Davis
United States

Keywords

Male, Narcotics, Dextroamphetamine, Diazepam, Ethanol, Morphine, Naloxone, Narcotic Antagonists, Methadyl Acetate, Haplorhini, Macaca mulatta, Naltrexone, Phenytoin, Animals, Cyclazocine, Humans, Drug Interactions, Female, Morphine Dependence, Methadone

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