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GUINEA PIGS AND CARCINOGENS

Name: GUINEA PIGS AND CARCINOGENS
Creator: Frej Stenbäck
Keywords: Adenosine Triphosphatases, 0301 basic medicine, Skin Neoplasms, Histocytochemistry, Fibrosarcoma, Acid Phosphatase, Guinea Pigs, 3. Good health, Lactones, Leucyl Aminopeptidase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1970Publisher:WileyJournal:Acta Pathologica Microbiologica Scandinavica Section A Pathology, volume 78A, pages 192-204 (issn: 0365-4184,

Authors: Frej Stenbäck;

doi: 10.1111/j.1699-0463.1970.tb00253.x

pmid: 4246749

GUINEA PIGS AND CARCINOGENS

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Abstract

The reaction of guinea pig skin to topical and subcutaneous administration of four carcinogens administered in different dosages to newborn and adult animals, has been investigated histologically and histochemically. The transplantability of the sarcomas produced, and the occurrence of spontaneous tumours in the strain used, was studied too. The guinea pig was resistant to topical carcinogen treatment, but large doses administered during a long period did induce tumorigenesis. The resulting tumours were all fibrosarcomas. The newborn animals were as resistant as adults. The transplantation of the tumours was successfull, but the percentage of positive “takes” was small. A single dermal tumour occurred spontaneously in the control group consisting of 500 animals.

Related Organizations

University of Oulu
Finland
Oulu University Hospital
Finland

Keywords

Adenosine Triphosphatases, Skin Neoplasms, Histocytochemistry, Fibrosarcoma, Acid Phosphatase, Guinea Pigs, Lactones, Leucyl Aminopeptidase, Animals, Newborn, Benz(a)Anthracenes, Carcinogens, Quinolines, Animals, Neoplasm Transplantation, Methylcholanthrene

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