Abstract:  Stress is an association of physiological and psychological reactions of a person confronted to a change of situation he cannot face. The relationship between stress and any disease is explained by hormonal modifications and behavioural changes induced by the stress. The evidence of such an association between stress and periodontal disease will be evaluated. The purpose of the present review article is to differentiate between old feelings and knowledge, and present findings which show that a lot of prospective studies are still needed for a more defined role of stress and periodontal disease.