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Sirolimus-Induced Angioedema

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2004 English Publisher:Elsevier BVJournal:American Journal of Transplantation, volume 4, pages 1,002-1,005 (issn: 1600-6135,

Authors: Hani M. Wadei; Scott A. Gruber; Jose M. El-Amm; Abdolreza Haririan; James Garnick; Darla K. Granger; Dale H. Sillix; +2 Authors

doi: 10.1111/j.1600-6143.2004.00429.x

pmid: 15147436

Sirolimus-Induced Angioedema

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Abstract

Sirolimus (SRL) is a macrolide immunosuppressant that has gained widespread use in organ transplantation. Its full spectrum of side-effects is yet to be defined. We describe herein three cases of SRL-induced angioedema (AE) in African-American (AA) primary renal allograft recipients who received SRL in combination with mycophenolate mofetil and steroids. In two cases, AE manifested after SRL was restarted after a period of discontinuation. The third case presented upon initial exposure to the drug. None of the patients was receiving any drug that has been previously associated with AE. Complete resolution occurred only after SRL was withdrawn. AE has not recurred in any of the patients during a follow-up period of up to 21 months. We conclude that AE is a previously unrecognized adverse event associated with SRL use. Close monitoring for this side-effect, especially in AA patients, is warranted.

Related Organizations

Wayne State College
United States
Wayne State University
United States
Harper University Hospital
United States

Keywords

Male, Postoperative Care, Sirolimus, Middle Aged, Mycophenolic Acid, Kidney Transplantation, Black or African American, Retreatment, Humans, Transplantation, Homologous, Drug Therapy, Combination, Angioedema, Immunosuppressive Agents, Follow-Up Studies

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	38
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%