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Chemokine receptor CCR5 in interferon-treated multiple sclerosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2007 Denmark Publisher:Hindawi LimitedJournal:Acta Neurologica Scandinavica, volume 115, pages 413-418 (issn: 0001-6314, eissn: 1600-0404,

Authors: Sellebjerg, F; Kristiansen, Thomas Birk; Wittenhagen, P; Garred, P; Eugen-Olsen, J; Frederiksen, J L; Sørensen, Torben Lykke;

doi: 10.1111/j.1600-0404.2007.00826.x

pmid: 17511851

Chemokine receptor CCR5 in interferon-treated multiple sclerosis

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Abstract

To study the relationship between CC chemokine receptor CCR5 expression and disease activity in multiple sclerosis (MS) patients treated with beta-interferon (IFN-beta).The CCR5 Delta32 allele and a CCR5 promoter polymorphism associated with cell surface expression of CCR5 were analyzed in 109 patients with relapsing-remitting MS treated with IFN-beta who were followed clinically for 1 year. Cellular CCR5 expression was measured by flow cytometry.Patients with MS had a higher percentage of CCR5-positive monocytes than healthy controls. Increased monocyte expression of CCR5 correlated weakly with an increased short-term relapse risk but there was no relationship between CCR5 Delta32 allele and CCR5 promoter polymorphism genotypes and relapse risk.The results do not support a major role of CCR5 in the pathogenesis of relapses in MS patients treated with IFN-beta, but it is possible that monocyte CCR5 expression may be used as a marker of disease activity.

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Denmark

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Keywords

Adult, Central Nervous System, Genetic Markers, Male, Multiple Sclerosis, Genotype, DNA Mutational Analysis, Relapsing-Remitting, Monocytes, Promoter Regions, Multiple Sclerosis, Relapsing-Remitting, Genetic, Gene Frequency, Receptors, Humans, Genetic Predisposition to Disease, Genetic Testing, Polymorphism, Promoter Regions, Genetic, Polymorphism, Genetic, Interferon-beta, Middle Aged, Mutation, Biological Markers, Female, Interferons, CCR5, Biomarkers

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