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THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1981Publisher:WileyJournal:British Journal of Pharmacology, volume 74, pages 715-721 (issn: 0007-1188, eissn: 1476-5381,

Authors: G. Pearson; M.C.W. Minchin;

doi: 10.1111/j.1476-5381.1981.tb10483.x

pmid: 6117345

pmc: PMC2071764

THE EFFECT OF THE CONVULSANT AGENT, CATECHOL, ON NEUROTRANSMITTER UPTAKE AND RELEASE IN RAT BRAIN SLICES

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Abstract

The effect of catechol on uptake and K+‐stimulated release of γ‐aminobutyric acid (GABA), D‐aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area. Noradrenaline release was unaffected by catechol. Acetylcholine release from both cortical and thalamic slices was inhibited by high concentrations of catechol. This phenomenon is unlikely to be related to catechol‐induced convulsions. Catechol (100 μm) inhibited GABA release from cortical slices by 28%. However, at a concentration of 10 μm catechol enhanced the release of D‐aspartate from thalamic slices by over 100%. Potentiated release of excitatory amino acid transmitters may contribute to the enhanced excitability of thalamic cells which occurs during sensory myoclonus induced by low doses of catechol.

Related Organizations

University of Sheffield
United Kingdom

Keywords

Male, Neurotransmitter Agents, Catechols, Brain, Convulsants, Rats, Inbred Strains, In Vitro Techniques, Acetylcholine, Rats, Norepinephrine, Potassium, Animals, Calcium, Amino Acids, gamma-Aminobutyric Acid

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