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Biotransformation of quinoxaline by Streptomyces badius

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1996 English Publisher:Oxford University Press (OUP)Journal:Letters in Applied Microbiology, volume 22, pages 199-201 (issn: 0266-8254, eissn: 1472-765X,

Authors: Sutherland, J. B.; Evans, F. E.; Freeman, J. P.; Williams, A. J.;

doi: 10.1111/j.1472-765x.1996.tb01142.x

pmid: 8852347

Biotransformation of quinoxaline by Streptomyces badius

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Abstract

Quinoxaline, a mutagenic azaarene produced in foods during cooking, was added to cultures of Streptomyces badius ATCC 39117. After 24 h, the cultures were extracted with ethyl acetate. Two major metabolites were purified by liquid chromatography and identified by mass spectrometry and nuclear magnetic resonance spectroscopy as 3,4-dihydro-2(1H)-quinoxalinone and 2(1H)-quinoxalinone.

Related Organizations

National Center for Toxicological Research
United States
United States Food and Drug Administration
United States

Keywords

Magnetic Resonance Spectroscopy, Quinoxalines, Biotransformation, Food Analysis, Mass Spectrometry, Streptomyces, Mutagens

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