Definition of DRw10 specificity by restriction fragment length polymorphism
Copyright policy )Definition of DRw10 specificity by restriction fragment length polymorphism
The purpose of this study was the RFLP characterization of the DRw10 specificity. Twenty‐two DRw10 cells were tested: the DNAs were digested by seven restriction enzymes and hybridized with DRβ, DQβ and DUα probes. Hybridizaton with DRβ revealed a pattern particular to the DRw10 specificity. with a specific Taql 12.5Kb fragment. Hybridization with both DQ‐specific probes showed that DRw10 is always associated with a special DOw1 subtype: DQw5. Furthermore. at DR and DQ levels, the 22 DRw10 cells behaved homogeneously.
Polymorphism, Genetic, Genetic Linkage, HLA-DR1 Antigen, HLA-DR6 Antigen, Nucleic Acid Hybridization, HLA-DR Antigens, Epitopes, Haplotypes, HLA-DQ Antigens, Humans, HLA-DR2 Antigen, Alleles, Polymorphism, Restriction Fragment Length
Polymorphism, Genetic, Genetic Linkage, HLA-DR1 Antigen, HLA-DR6 Antigen, Nucleic Acid Hybridization, HLA-DR Antigens, Epitopes, Haplotypes, HLA-DQ Antigens, Humans, HLA-DR2 Antigen, Alleles, Polymorphism, Restriction Fragment Length
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