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The Cytology of Langerhans Cell Histiocytosis (Histiocytosis X)

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1991Publisher:WileyJournal:Cytopathology, volume 2, pages 149-158 (issn: 0956-5507, eissn: 1365-2303,

Authors: R Maarten Egeler; P. Van Heerde;

doi: 10.1111/j.1365-2303.1991.tb00399.x

pmid: 1932578

The Cytology of Langerhans Cell Histiocytosis (Histiocytosis X)

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Abstract

The cytomorphology of 13 cases of Langerhans cell histiocytosis is described. the most striking features were the presence of intranuclear clefts, pale nuclei and inconspicuous nucleoli, together with ample pale cytoplasm, only slight cellular pleomorphism, and an admixture of varying numbers of eosinophils, macrophages and degenerated cells.In 13 of 16 cases investigated ultrastructurally, characteristic Birbeck granules were detected. Out of six cases tested, four exhibited positivity for S‐100, and of three cases tested, all were positive for CD1a (leu 6) and HLA‐DR. In one case malignant transformation occurred, terminating in monocytic leukaemia.

Related Organizations

Antoni van Leeuwenhoek Hospital
Netherlands
Academic Medical Center
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Netherlands Heart Institute
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Emma Kinderziekenhuis
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Keywords

Adult, Male, Adolescent, Infant, Newborn, Infant, Middle Aged, Immunohistochemistry, Histiocytosis, Langerhans-Cell, Islets of Langerhans, Microscopy, Electron, Cell Transformation, Neoplastic, Humans, Female

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%