descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1985 English Publisher:Oxford University Press (OUP)Journal:Clinical and Experimental Dermatology, volume 10, pages 121-126 (issn: 0307-6938, eissn: 1365-2230,

Authors: Kristian Thomsen; Gunhild Lange Wantzin; Elisabeth Ralfkiaer; Jørgen K. Larsen;

doi: 10.1111/j.1365-2230.1985.tb00539.x

pmid: 3978861

Clonal evolution in cutaneous malignant histiocytosis

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Abstract

Summary A 56–year-old woman is reported with malignant histiocytosis which for 17 months was confined to the skin but eventually involved lymph nodes, blood and bone marrow. Using DN'A measurements by flow cytometry a clonal evolution from an abnormal hyperdiploid to a hypotetraploid cell clone took place when the patient went from the cutaneous to the disseminated phase of the disease. Thus DNA measurements upon tumours may predict the transition from the cutaneous to the disseminated stage.

Related Organizations

Finsen Laboratory

Keywords

Ploidies, Skin Neoplasms, Humans, Female, Neoplasm Invasiveness, DNA, Neoplasm, Middle Aged, Lymphatic Diseases

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