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Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?

descriptionPublicationkeyboard_double_arrow_right Article 11 Nov 2004Publisher:WileyJournal:Immunological Reviews, volume 202, pages 223-236 (issn: 0105-2896, eissn: 1600-065X,

Authors: Giorgio Trinchieri; Alain Vicari;

doi: 10.1111/j.0105-2896.2004.00216.x

pmid: 15546396

Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?

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Abstract

Summary: Interleukin‐10 (IL‐10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL‐10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL‐10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.

Related Organizations

Schering-Plough
United States

Keywords

Blood Cells, Virus Diseases, Neoplasms, Tumor Cells, Cultured, Humans, Interleukin-10

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	100
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%