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Journal of Investigative Dermatology
Article
License: Elsevier Non-Commercial
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Journal of Investigative Dermatology
Article . 2005
License: Elsevier Non-Commercial
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Journal of Investigative Dermatology
Article . 2005 . Peer-reviewed
License: Elsevier Non-Commercial
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The SNPs of RAF

Authors: Hensin Tsao;

The SNPs of RAF

Abstract

Imagine a deck of new cards perfectly sequenced from One of Clubs to the Ace of Spades. Shuffle once (overhand method), and most cards are still in order, e.g., ... 9, 10, Jack, King, Queen, Ace of Spades. Shuffle twice, three times, and so on and more and more randomness is introduced into the deck. Cards that are juxtaposed next to one another, e.g., King and Ace of Spades will likely travel together through multiple shufflings as a card has to be precisely inserted between the two for the arrangement to be disrupted. But, the One of Spades is likely to fall out of sequence relative to the Ace of Spades early in the shuffling process as the likelihood that a random card is inserted between a One and Ace is quite high. Thus, even in a simple game of cards, near neighbors travel together for longer periods of time and much more shuffling is required to separate the two than far neighbors.

Related Organizations
Keywords

Proto-Oncogene Proteins B-raf, Mutation, Humans, raf Kinases, Cell Biology, Dermatology, Biochemistry, Molecular Biology, Polymorphism, Single Nucleotide

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
hybrid