Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes
Copyright policy )Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes
Avian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969‐78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild‐type levels.
- The University of Hong Kong China (People's Republic of)
- The University of Hong Kong
- University of Hong Kong China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- The University of Hong Kong
Fractional factorial design, Influenza A Virus, H3N2 Subtype, Short Articles, Influenza A Virus, H7N9 Subtype, H7N9, Influenza polymerase, Viral Proteins, Influenza A Virus, H1N1 Subtype, Ribonucleoproteins, Influenza, Human, Humans, Reassortant Viruses
Fractional factorial design, Influenza A Virus, H3N2 Subtype, Short Articles, Influenza A Virus, H7N9 Subtype, H7N9, Influenza polymerase, Viral Proteins, Influenza A Virus, H1N1 Subtype, Ribonucleoproteins, Influenza, Human, Humans, Reassortant Viruses
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