Immune signalling by supramolecular assemblies
Copyright policy )Immune signalling by supramolecular assemblies
SummaryFormation of supramolecular assemblies appears to be a general mechanism in immune signalling pathways. These supramolecular assemblies appear to form through a nucleated polymerization mechanism. This review examines selected immune signalling pathways that involve supramolecular assemblies, describes the concepts of protein polymerization, and discusses how those concepts of protein polymerization implicate new elegant ways for signal amplification, setting threshold and noise reduction in these pathways.
- University of the Sciences United States
- University of California, San Francisco United States
- Centre for Cellular and Molecular Biology India
Inflammasomes, Protein Biosynthesis, Cytokines, Humans, Receptors, Cell Surface, Protein Multimerization, Signal Transduction
Inflammasomes, Protein Biosynthesis, Cytokines, Humans, Receptors, Cell Surface, Protein Multimerization, Signal Transduction
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