Cytomegalovirus‐associated thrombocytopenia treated with thrombopoietin receptor agonist

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2016 English Publisher:WileyJournal:Internal Medicine Journal, volume 46, pages 1,096-1,099 (issn: 1444-0903, eissn: 1445-5994,

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Authors: J. D. Simpson; G. V. Matthews; T. A. Brighton; J. E. Joseph;

doi: 10.1111/imj.13181

pmid: 27633469

Cytomegalovirus‐associated thrombocytopenia treated with thrombopoietin receptor agonist

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Abstract

Symptomatic cytomegalovirus (CMV) in immunocompetent individuals is an uncommon, yet recognised, phenomenon. This report discusses a case of CMV‐associated thrombocytopenia refractory to immunomodulation and antivirals. Ultimately, a clinicopathological response was attained with eltrombopag. This is the first report of the efficacy of thrombopoietin receptor agonists in this context. This experience provides insight into possible pathogenic mechanisms of CMV‐associated thrombocytopenia and presents a therapeutic option.

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UNSW Sydney
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St. Vincent's Health System
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Keywords

Purpura, Thrombocytopenic, Idiopathic, Cytomegalovirus, Middle Aged, Antiviral Agents, Benzoates, Hydrazines, Cytomegalovirus Infections, Humans, Prednisone, Pyrazoles, Female, Receptors, Thrombopoietin

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