The ideal migraine medication would provide rapid “one and done” treatment of migraine for all sufferers. Unfortunately, no such intervention is available. While most people respond to triptans or DHE, some will need to combine these with an NSAID, or will choose to use an NSAID alone because of personal preference or for medical reasons. Dopamine blockers are another option, and combined with any of the other treatments or used alone, may be particularly useful in those with vascular disease.