AbstractIn the present work, comprehensive investigation of both theoretical analysis and numerical simulation was carried out to investigate the plastic mismatch effect on plasticity induced crack closure (PICC) behavior and effective fatigue crack tip driving force. During the process of crack tip approaching interface, crack tip load and crack tip load ratio will change, resulting in the change of PICC degree. When the crack propagates towards higher strength side,Kop/Kmaxincreases; when the crack propagates towards lower strength side,Kop/Kmaxdecreases firstly and then increases. The two mechanisms of “interface plastic mismatch effect on nominal fatigue crack tip driving force” and “interface plastic mismatch effect on PICC degree” were compared. The second mechanism must be considered when building crack tip driving force model for describing fatigue crack crossing plastically mismatched interface, because it is more physically factual and maybe more important than the first mechanism.