Epithelial cells acquire mesenchymal characteristics during embryonic development, wound healing, fibrosis, and in cancer in a processed termed epithelial‐to‐mesenchymal transition (EMT). Regulatory networks of EMT are controlled by post‐transcriptional, translational, and post‐translational mechanisms, in which arginine methylation is critically involved. Here, we review arginine methylation‐dependent mechanisms that regulate EMT in the aspects of signaling, transcriptional, and splicing regulation.