Epithelial‐to‐mesenchymal‐like transition events in melanoma
Copyright policy )Epithelial‐to‐mesenchymal‐like transition events in melanoma
Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that nonepithelial tumors, including melanoma, can also gain mesenchymal‐like properties that increase their metastatic propensity and decrease their sensitivity to therapy. In this review, we discuss recent findings, illustrating the striking similarities—but also knowledge gaps—between the biology of mesenchymal‐like state(s) in melanoma and mesenchymal state(s) from epithelial cancers. Based on this comparative analysis, we suggest hypothesis‐driven experimental approaches to further deepen our understanding of the EMT‐like process in melanoma and how such investigations may pave the way towards the identification of clinically relevant biomarkers for prognosis and new therapeutic strategies.
- KU Leuven Belgium
- VIB Belgium
- Katholieke Universiteit Leuven Belgium
- Université Libre de Bruxelles Belgium
GENE-EXPRESSION PROGRAMS, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, Epithelial-Mesenchymal Transition, Skin Neoplasms, METASTATIC COLONIZATION, Biochimie, THERAPEUTIC RESISTANCE, NF-KAPPA-B, Antineoplastic Agents, 0601 Biochemistry and Cell Biology, INITIATING CELLS, phenotype switching, 3205 Medical biochemistry and metabolomics, PHENOTYPIC PLASTICITY, melanoma, Biomarkers, Tumor, Humans, Molecular Targeted Therapy, Neoplasm Metastasis, Melanoma, 3404 Medicinal and biomolecular chemistry, Science & Technology, NEURAL CREST, 0304 Medicinal and Biomolecular Chemistry, MITF TRANSCRIPTION FACTORS, EMT, Biologie moléculaire, Cell Differentiation, Epithelial Cells, Mesenchymal Stem Cells, CIRCULATING TUMOR-CELLS, Neoplasm Proteins, WAARDENBURG-SYNDROME, Gene Expression Regulation, Neoplastic, 1101 Medical Biochemistry and Metabolomics, Drug Resistance, Neoplasm, C16/19/006, Neoplastic Stem Cells, Biologie cellulaire, Life Sciences & Biomedicine, Transcription Factors
GENE-EXPRESSION PROGRAMS, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, Epithelial-Mesenchymal Transition, Skin Neoplasms, METASTATIC COLONIZATION, Biochimie, THERAPEUTIC RESISTANCE, NF-KAPPA-B, Antineoplastic Agents, 0601 Biochemistry and Cell Biology, INITIATING CELLS, phenotype switching, 3205 Medical biochemistry and metabolomics, PHENOTYPIC PLASTICITY, melanoma, Biomarkers, Tumor, Humans, Molecular Targeted Therapy, Neoplasm Metastasis, Melanoma, 3404 Medicinal and biomolecular chemistry, Science & Technology, NEURAL CREST, 0304 Medicinal and Biomolecular Chemistry, MITF TRANSCRIPTION FACTORS, EMT, Biologie moléculaire, Cell Differentiation, Epithelial Cells, Mesenchymal Stem Cells, CIRCULATING TUMOR-CELLS, Neoplasm Proteins, WAARDENBURG-SYNDROME, Gene Expression Regulation, Neoplastic, 1101 Medical Biochemistry and Metabolomics, Drug Resistance, Neoplasm, C16/19/006, Neoplastic Stem Cells, Biologie cellulaire, Life Sciences & Biomedicine, Transcription Factors
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