Regulation of the mammalian heat shock factor 1
Copyright policy )Regulation of the mammalian heat shock factor 1
Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription factor heat shock factor 1 (HSF1) mediates the elevation of heat shock proteins, which are crucial components of the chaperone complex machinery and function to ameliorate protein misfolding and aggregation and restore protein homeostasis. In addition, HSF1 orchestrates a versatile transcriptional programme that includes genes involved in repair and clearance of damaged macromolecules and maintenance of cell structure and metabolism, and provides protection against a broad range of cellular stress mediators, beyond heat shock. Here, we discuss the structure and function of the mammalian HSF1 and its regulation by post‐translational modifications (phosphorylation, sumoylation and acetylation), proteasomal degradation, and small‐molecule activators and inhibitors.
- University of Dundee United Kingdom
- Johns Hopkins Medicine United States
- Johns Hopkins University School of Medicine United States
Models, Molecular, 570, Proteasome Endopeptidase Complex, Protein Folding, Hot Temperature, Transcription, Genetic, Protein Conformation, 610, phytochemical, HSF1 activator, cytoprotection, sulfhydryl reactivity, Heat Shock Transcription Factors, hormesis, Stress, Physiological, Animals, Phosphorylation, Phylogeny, Mammals, Sumoylation, Acetylation, Adaptation, Physiological, DNA-Binding Proteins, Gene Expression Regulation, HSF1 inhibitor, Protein Processing, Post-Translational, Transcription Factors
Models, Molecular, 570, Proteasome Endopeptidase Complex, Protein Folding, Hot Temperature, Transcription, Genetic, Protein Conformation, 610, phytochemical, HSF1 activator, cytoprotection, sulfhydryl reactivity, Heat Shock Transcription Factors, hormesis, Stress, Physiological, Animals, Phosphorylation, Phylogeny, Mammals, Sumoylation, Acetylation, Adaptation, Physiological, DNA-Binding Proteins, Gene Expression Regulation, HSF1 inhibitor, Protein Processing, Post-Translational, Transcription Factors
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