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FEBS Journal
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FEBS Journal
Article . 2014 . Peer-reviewed
Data sources: Crossref
FEBS Journal
Article . 2015
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Programmed necrosis and necroptosis signalling

Authors: Maria, Feoktistova; Martin, Leverkus;

Programmed necrosis and necroptosis signalling

Abstract

In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 ( RIPK 1), RIPK 3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK 1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.

Keywords

Mitochondrial Permeability Transition Pore, Toll-Like Receptors, Apoptosis, Receptors, Death Domain, Mitochondrial Membrane Transport Proteins, Models, Biological, Receptors, Tumor Necrosis Factor, Mice, Necrosis, Multiprotein Complexes, Receptor-Interacting Protein Serine-Threonine Kinases, Animals, Humans, Protein Kinases, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    The total number of citations received by all articles of the researcher of interest.
    157
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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citations
The total number of citations received by all articles of the researcher of interest.
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
157
Top 1%
Top 10%
Top 1%
bronze