
doi: 10.1111/febs.13120
pmid: 25327580
In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 ( RIPK 1), RIPK 3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK 1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.
Mitochondrial Permeability Transition Pore, Toll-Like Receptors, Apoptosis, Receptors, Death Domain, Mitochondrial Membrane Transport Proteins, Models, Biological, Receptors, Tumor Necrosis Factor, Mice, Necrosis, Multiprotein Complexes, Receptor-Interacting Protein Serine-Threonine Kinases, Animals, Humans, Protein Kinases, Signal Transduction
Mitochondrial Permeability Transition Pore, Toll-Like Receptors, Apoptosis, Receptors, Death Domain, Mitochondrial Membrane Transport Proteins, Models, Biological, Receptors, Tumor Necrosis Factor, Mice, Necrosis, Multiprotein Complexes, Receptor-Interacting Protein Serine-Threonine Kinases, Animals, Humans, Protein Kinases, Signal Transduction
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