Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells

descriptionPublicationkeyboard_double_arrow_right Article 16 Aug 2017 English Publisher:WileyJournal:Fundamental & Clinical Pharmacology, volume 31, pages 695-700 (issn: 0767-3981, eissn: 1472-8206,

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Authors: Tao Song; Yuanyuan Zhang; Qiongtao Song; Xue Han; Shengjiang Guan; Xuan Zhang; Xi Chu; +3 Authors

doi: 10.1111/fcp.12306

pmid: 28755515

Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells

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Abstract

AbstractIn this study, we investigated the effect of bufalin on the human ether‐à‐go‐go‐related gene (hERG) K+ channels using the perforated patch recording technique. We measured a half‐maximal inhibitory concentration (IC50) of 24.83 μM and maximal inhibitory effect of 39.45 ± 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K+ channel blocker and may provide a new way for understanding Chan Su‐induced arrhythmia.

Related Organizations

Hebei University
China (People's Republic of)
Fourth Hospital of Hebei Medical University
China (People's Republic of)
Hebei Medical University
China (People's Republic of)
Hebei University
China (People's Republic of)
Hebei University of Chinese Medicine
China (People's Republic of)

Keywords

Calcium Channels, L-Type, Arrhythmias, Cardiac, Bufanolides, HEK293 Cells, Animals, Humans, Parotid Gland, Steroids, Anura, Medicine, Chinese Traditional

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