Peptidylarginine deiminases and deiminated proteins at the epidermal barrier
Copyright policy )Peptidylarginine deiminases and deiminated proteins at the epidermal barrier
AbstractDeimination or citrullination is a post‐translational modification catalysed by a family of calcium‐dependent enzymes called peptidylarginine deiminases (PADs). It corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Deimination induces a decreased net charge of targeted proteins; therefore, it alters their folding and changes intra‐ and intermolecular ionic interactions. Deimination is involved in several physiological processes (inflammation, gene regulation, etc.) and human diseases (rheumatoid arthritis, neurodegenerative diseases, cancer, etc.). Here, we describe the PADs expressed in the epidermis and their known substrates, focusing on their role in the epidermal barrier function.
filaggrin, citrullination, Calcium / metabolism, Neurodegenerative Diseases / metabolism, Hydrolases, Filaggrin Proteins, Arginine, Arthritis, Rheumatoid, Mice, Neoplasms, Animals, Humans, peptidylarginine deiminase, Arginine / metabolism, Neoplasms / metabolism, Inflammation, Arthritis, Rheumatoid / metabolism, deimination, keratinocyte differentiation, Gene Expression Profiling, Protein-Arginine Deiminases / metabolism*, Neurodegenerative Diseases, Epidermal Cells / metabolism, Citrulline / metabolism, S100-fused type proteins, post-translational modification, Epidermal Cells, Gene Expression Regulation, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Protein-Arginine Deiminases, Citrulline, Calcium, Epidermis, Hydrolases / metabolism, Epidermis / enzymology*, Protein Processing, Post-Translational
filaggrin, citrullination, Calcium / metabolism, Neurodegenerative Diseases / metabolism, Hydrolases, Filaggrin Proteins, Arginine, Arthritis, Rheumatoid, Mice, Neoplasms, Animals, Humans, peptidylarginine deiminase, Arginine / metabolism, Neoplasms / metabolism, Inflammation, Arthritis, Rheumatoid / metabolism, deimination, keratinocyte differentiation, Gene Expression Profiling, Protein-Arginine Deiminases / metabolism*, Neurodegenerative Diseases, Epidermal Cells / metabolism, Citrulline / metabolism, S100-fused type proteins, post-translational modification, Epidermal Cells, Gene Expression Regulation, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Protein-Arginine Deiminases, Citrulline, Calcium, Epidermis, Hydrolases / metabolism, Epidermis / enzymology*, Protein Processing, Post-Translational
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