Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2018 English Publisher:WileyJournal:Experimental Dermatology, volume 27, pages 327-331 (issn: 0906-6705, eissn: 1600-0625,

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Authors: Chisa Nakashima; Atsushi Otsuka; Kenji Kabashima;

doi: 10.1111/exd.13533

pmid: 29524262

Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis

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Abstract

AbstractAtopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin lesions caused by skin barrier dysfunction and T helper (Th)2 cell‐mediated immunity. Interleukin (IL)‐31 is a potent pruritogenic cytokine primarily produced by Th2 cells. Both IL‐31 transgenic mice and wild‐type mice treated with IL‐31 exhibit AD‐like skin lesions and scratching behaviour. IL‐31 receptor α‐chain (IL‐31RA) is also expressed in peripheral nerves and epidermal keratinocytes, and the roles of IL‐31 on pruritus and skin barrier have been investigated. Recently, an anti–IL‐31 receptor antibody was shown to significantly improve pruritus in AD patients. This review focuses on IL‐31 and IL‐31RA in AD.

Related Organizations

Kyoto University
Japan
Agency for Science, Technology and Research
Singapore
Institute of Medical Biology
Singapore

Keywords

Keratinocytes, Interleukins, Pruritus, Antipruritics, Receptors, Interleukin, Antibodies, Monoclonal, Humanized, Basophils, Dermatitis, Atopic, Eosinophils, Humans, Mast Cells, Molecular Targeted Therapy

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