SummaryThe International League Against Epilepsy (ILAE)NeuropsychobiologyCommission gave the charge to provide practical guidance for health professionals for the pharmacologic and nonpharmacologic treatment of patients with psychogenic nonepileptic seizures (PNES). Using a consensus review of the literature, an international group of clinician‐researchers in epilepsy, neurology, neuropsychology, and neuropsychiatry evaluated key management approaches forPNES. These included the following: presentation of the diagnosis, early phase treatment, psychological and pharmacologic interventions, and maintenance management. The aim of this report is to provide greater clarity about the range and current evidence base for treatment for patients withPNES, with the intention of improving the care of patients withPNESand patients who developPNESas a comorbidity of epilepsy.