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European Journal of Neurology
Article . 2023 . Peer-reviewed
License: CC BY NC ND
Data sources: Crossref
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Iatrogenic cerebral amyloid angiopathy: An illustrative case of a newly introduced disease

Authors: Benedetta Storti; Isabella Canavero; Maria Magdalena Gabriel; Antonella Capozza; Nicola Rifino; Mario Stanziano; Luca Tagliabue; +1 Authors

Iatrogenic cerebral amyloid angiopathy: An illustrative case of a newly introduced disease

Abstract

AbstractBackground and purposeIatrogenic cerebral amyloid angiopathy (iCAA) is a specific type of cerebral amyloid angiopathy which is becoming increasingly diagnosed. It has been hypothesized that iCAA might arise as a late consequence of past neurosurgical interventions involving dural patch grafts. Positron emission tomography (PET) scans with amyloid tracers and the assay of beta‐amyloid levels in cerebrospinal fluid (CSF) are auxiliary criteria, however, definite diagnosis remains histopathologically determined.MethodsCase report.ResultsWe present a 48‐year‐old patient who suffered multiple lobar cerebral haemorrhages from the age of 47. The patient had undergone surgery for remolval of hemangioblastoma with lyophilized dural graft at the age of 11, in 1987. Brain MRI, amiloid PET and CSF analysis led to a diagnosis of probable iCAA.ConclusionIt is necessary to increase the awareness of iCAA, in order to avoid overlooking the potential causal involvement of surgical procedures which took place far back in time. Moreover, the diagnostic relevance of amyloid PET and beta‐amyloid levels in CSF must be emphasised.

Keywords

Cerebral Amyloid Angiopathy, Amyloid beta-Peptides, Iatrogenic Disease, Humans, Middle Aged, Magnetic Resonance Imaging, Cerebral Hemorrhage

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Top 10%
Top 10%
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