John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients
Copyright policy )John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients
Background and purposeInfection with the John Cunningham virus (JCV) is required for the development of progressive multifocal leukoencephalopathy, the feared complication of natalizumab treatment in multiple sclerosis patients. The JCV seroconversion rate seems higher in natalizumab treated patients than in the normal population, with an unknown cause.MethodsNatalizumab concentration was correlated to JCV antibody status and seroconversion in a large cohort of multiple sclerosis patients.ResultsOne hundred and thirty‐five patients were included. No correlation was found between natalizumab concentration and JCV status, JCV seroconversion or JCV index.ConclusionsHigher natalizumab concentrations do not explain the increased JCV seroconversion rate in natalizumab treated patients.
- University of Amsterdam Netherlands
- Amsterdam UMC Netherlands
- Amsterdam UMC, location VUmc Netherlands
- Amsterdam Neuroscience Netherlands
- Vrije Universiteit Amsterdam Netherlands
Adult, Male, Risk, Multiple Sclerosis, Natalizumab, Leukoencephalopathy, Progressive Multifocal, JC virus, Middle Aged, multiple sclerosis, Antibodies, Viral, JC Virus, Cohort Studies, natalizumab, Humans, Immunologic Factors, Female, Prospective Studies
Adult, Male, Risk, Multiple Sclerosis, Natalizumab, Leukoencephalopathy, Progressive Multifocal, JC virus, Middle Aged, multiple sclerosis, Antibodies, Viral, JC Virus, Cohort Studies, natalizumab, Humans, Immunologic Factors, Female, Prospective Studies
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