Mechanisms and disease relevance of neutrophil extracellular trap formation

descriptionPublicationkeyboard_double_arrow_right Article 02 Apr 2018 English Publisher:WileyJournal:European Journal of Clinical Investigation, volume 48 (issn: 0014-2972, eissn: 1365-2362,

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Authors: Kristof Van Avondt; Dominik Hartl;

doi: 10.1111/eci.12919

pmid: 29543328

Mechanisms and disease relevance of neutrophil extracellular trap formation

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Abstract

AbstractWhile the microscopic appearance of neutrophil extracellular traps (NETs) has fascinated basic researchers since its discovery, the (patho)physiological mechanisms triggering NET release, the disease relevance and clinical translatability of this unconventional cellular mechanism remained poorly understood. Here, we summarize and discuss current concepts of the mechanisms and disease relevance of NET formation.

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Keywords

Cell Death, Mycoses, Neutrophils, Humans, Bacterial Infections, Extracellular Traps, Autoimmune Diseases, Forecasting, Signal Transduction

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