The eyes are an important component of facial aesthetics. They are in the center of an anatomical area of the face very important for rejuvenation procedures, the so-called "periorbital region." The appearance of the eyes therefore decisively influences the perception of the aesthetics and aging of the entire face. In juvenile age, the skin of the periocular area is elastic and tonic, without sun damage; the eyebrow is full, well defined, and not descending; there is a clear and visible fold of the upper eyelid, with minimal dermatochalasis; the lower eyelid is tense and well positioned. The aim of this preliminary study is to define a protocol for the use of plasma technology in the treatment of aging signs of the periorbital region. The protocol is aimed to provide predictable, constant, and safe results.