
doi: 10.1111/cup.12272
pmid: 24372009
Intercellular epidermal deposition of immunoglobulin G (IgG) in a continuous net‐like or ‘chicken wire’ pattern is a well‐described and diagnostic finding in direct immunofluorescence (DIF) studies of pemphigus. In our experience, punctate or dot‐like intercellular deposition of IgG can also be seen in cases of pemphigus but has received little attention in the literature. We describe a series of DIF specimens showing intercellular deposition of IgG in continuous and/or punctate patterns, which occurred with equal frequency in pemphigus vulgaris and pemphigus foliaceus. This series highlights the punctate or dot‐like pattern of intercellular IgG deposition in DIF studies of pemphigus, reviews potential mechanisms and calls attention to this potentially under‐recognized phenomenon.
Male, Immunoglobulin G, Humans, Female, Immunohistochemistry, Pemphigus, Retrospective Studies
Male, Immunoglobulin G, Humans, Female, Immunohistochemistry, Pemphigus, Retrospective Studies
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