Mechanisms of Panax ginseng action as an antidepressant

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 10 Oct 2019 English Publisher:WileyJournal:Cell Proliferation, volume 52 (issn: 0960-7722, eissn: 1365-2184,

Copyright policy )

Authors: Yang Jin; Ranji Cui; Lihong Zhao; Jie Fan; Bingjin Li;

doi: 10.1111/cpr.12696

pmid: 31599060

pmc: PMC6869450

Mechanisms of Panax ginseng action as an antidepressant

- Summary
- Subjects
- Metrics

Abstract

AbstractObjectivesPanax ginseng, a well‐known traditional Chinese medicine with multiple pharmacological activities, plays a crucial role in modulating mood disorders. Several recent studies have identified an underlying role of Panax ginseng in the prevention and treatment of depression. However, the cellular and molecular mechanisms remain unclear.Materials and MethodsIn this review, we summarized the recent progress of antidepressant effects and underlying mechanisms of Panax ginseng and its representative herbal formulae.ResultsThe molecular and cellular mechanisms of Panax ginseng and its herbal formulae include modulating monoamine neurotransmitter system, upregulating the expression of neurotrophic factors, regulating the function of HPA axis, and anti‐inflammatory action.ConclusionsTherefore, this review may provide theoretical bases and clinical applications for the treatment of depression by Panax ginseng and its representative herbal formulae.

Related Organizations

Jilin University
China (People's Republic of)
Jilin University
China (People's Republic of)

Keywords

Inflammation, Hypothalamo-Hypophyseal System, Depression, Plant Extracts, Animals, Humans, Panax, Review, Antidepressive Agents

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	105
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%