AbstractAimsThe patient being minimally conscious state (MCS) may benefit from wake‐up interventions aimed at improving quality of life and have a higher probability of recovering higher level of consciousness compared to patients with the unresponsive wakefulness syndrome (UWS). However, differentiation of the MCS and UWS poses challenge in clinical practice. This study aimed to explore glucose metabolic pattern (GMP) obtained from 18F‐labeled‐fluorodeoxyglucose positron emission tomography (18F‐FDG‐PET) in distinguishing between UWS and MCS.MethodsFifty‐seven patients with disorders of consciousness (21 cases of UWS and 36 cases of MCS) who had undergone repeated standardized Coma Recovery Scale‐Revised (CRS‐R) evaluations were enrolled in this prospective study. 18F‐FDG‐PET was carried out in all patients and healthy controls (HCs). Voxel‐based scaled subprofile model/principal component analysis (SSM/PCA) was used to generate GMPs. The expression score of whole‐brain GMP was obtained, and its diagnostic accuracy was compared with the standardized uptake value ratio (SUVR). The diagnostic efficiency was validated by one‐year later clinical outcomes.ResultsUWS‐MCS GMP exhibited hypometabolism in the frontal–parietal cortex, along with hypermetabolism in the unilateral lentiform nucleus, putamen, and anterior cingulate gyrus. The UWS‐MCS‐GMP expression score was significantly higher in UWS compared to MCS patients (0.90 ± 0.85 vs. 0 ± 0.93, p < 0.001). UWS‐MCS‐GMP expression score achieved an area under the curve (AUC) of 0.77 to distinguish MCS from UWS, surpassing that of SUVR based on the frontoparietal cortex (AUC = 0.623). UWS‐MCS‐GMP expression score was significantly correlated with the CRS‐R score (r = −0.45, p = 0.004) and accurately predicted the one‐year outcome in 73.7% of patients.ConclusionUWS and MCS exhibit specific glucose metabolism patterns, the UWS‐MCS‐GMP expression score significantly distinguishes MCS from UWS, making SSM/PCA a potential diagnostic methods in clinical practice for individual patients.