AbstractBackgroundThe biomechanical behavior of implant‐supported titanium and zirconia full‐arch fixed dental prosthesis (FAFDP) frameworks require further investigation.PurposeStrains transferred by implant‐supported titanium (Ti) and zirconia (Zr) FAFDP frameworks were analyzed.Materials and MethodsMaxillary 14‐unit FAFDPs supported by 6 implants and 12‐unit FAFDPs supported by 4 implants were tested. One‐piece frameworks were fabricated by computer‐aided design/computer‐aided manufacturing. Four groups were divided (n = 3): G1, Ti‐6 implants; G2, Zr‐6 implants; G3, Ti‐4 implants; G4, Zr‐4 implants. A 250 N single‐point load was applied on the second premolar. A three‐dimensional digital image correlation system recorded framework and maxilla model surface deformation.ResultsThe following strains (μS) averaged over the length of the second premolar were calculated: frameworks, G1 (321.82 ± 111.29), G2 (638.87 ± 108.64), G3 (377.77 ± 28.64), G4 (434.18 ± 132.21); model surface, G1 (473.99 ± 48.69), G2 (653.93 ± 45.26), G3 (1082.50 ± 71.14), G4 (1218.26 ± 230.37). Zirconia frameworks supported by 6 implants (G2) presented higher surface strains (P < .05). FAFDPs with titanium frameworks transferred significantly lower strains to the supporting maxilla when 6 implants were used (G1) (P < .05). Both framework materials transferred similar strains when supported by 4 implants (G3 and G4) (P > .05).ConclusionsZirconia frameworks supported by 6 implants showed higher strains. FAFDPs supported by 6 implants transferred less strains to the supporting maxilla, irrespective of framework material.