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Clinical and Experimental Ophthalmology
Article . 2023 . Peer-reviewed
License: CC BY NC ND
Data sources: Crossref
UQ eSpace
Article . 2023
Data sources: UQ eSpace
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Treatment of dry age‐related macular degeneration: A review

Authors: Shenouda Girgis; Lawrence R. Lee;

Treatment of dry age‐related macular degeneration: A review

Abstract

AbstractAge‐related macular degeneration is a global disease with a significant societal impact. The advent of anti‐vascular endothelial growth factor therapy (anti‐VEGF) has revolutionised the treatment of neovascular age‐related macular degeneration (nAMD). Dry age‐related macular degeneration (dAMD) is being investigated for possible therapeutic options. The therapeutic categories undergoing clinical trials include complement pathway inhibitors, visual cycle modulators, reduction of toxic byproducts, antioxidative therapy, neuroprotective agents, laser therapy, surgical options, gene therapy, stem cell therapy, and miscellaneous treatments. Two intravitreal anti‐complement factors (pegcetacoplan and avacincaptad pegol) have recently shown phase 3 clinical trial evidence of a reduction in the growth of geographic atrophy. In this review, we provide an update on treatment options currently undergoing clinical research trials for the management of dAMD and preventing the progression of Geographic Atrophy (GA).

Keywords

age-related macular degeneration (AMD), Macular Degeneration, Geographic Atrophy, Intravitreal Injections, dry age-related macular degeneration, Wet Macular Degeneration, Humans, Angiogenesis Inhibitors, 2731 Ophthalmology, complement inhibitors

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
49
Top 1%
Top 10%
Top 1%
hybrid
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