Hymenoptera venom immunotherapy (VIT) is the only effective treatment to prevent systemic reactions (SR) and anaphylaxis from insect stings. The efficacy of VIT is well established, with success rates of 77%–84% for bee venom and 90%–95% for wasp venom [1, 2]. However, conventional updosing protocols are lengthy, requiring 15–25 weeks to complete [3]. The frequency of systemic adverse events with VIT ranges from 5% to 20% across studies, most frequently occurring during updosing [4].