Mechanisms of Dupilumab
Copyright policy )Mechanisms of Dupilumab
AbstractThe Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL‐4 receptor alpha chain (IL‐4Rα), common to both IL‐4R complexes: type 1 (IL‐4Rα/γc; IL‐4 specific) and type 2 (IL‐4Rα/IL‐13Rα1; IL‐4 and IL‐13 specific). In this review, we detail the current state of knowledge of the different signalling pathways coupled to the IL‐4R complexes and examine the possible mechanisms of Dupilumab action and survey its clinical efficacy in different allergic disorders. The development of Dupilumab and the widening spectrum of its clinical applications is relevant to the current emphasis on precision medicine approaches to the blockade of pathways involved in allergic diseases.
- Harvard University United States
- Boston Children's Hospital United States
Inflammation, Interleukin-13, Interleukin-4 Receptor alpha Subunit, Eosinophilic Esophagitis, Antibodies, Monoclonal, Humanized, Rhinitis, Allergic, T-Lymphocytes, Regulatory, Asthma, Dermatitis, Atopic, Nasal Polyps, Th2 Cells, Anti-Allergic Agents, Chronic Disease, Humans, Interleukin-4, Sinusitis, STAT6 Transcription Factor, Anaphylaxis, Food Hypersensitivity
Inflammation, Interleukin-13, Interleukin-4 Receptor alpha Subunit, Eosinophilic Esophagitis, Antibodies, Monoclonal, Humanized, Rhinitis, Allergic, T-Lymphocytes, Regulatory, Asthma, Dermatitis, Atopic, Nasal Polyps, Th2 Cells, Anti-Allergic Agents, Chronic Disease, Humans, Interleukin-4, Sinusitis, STAT6 Transcription Factor, Anaphylaxis, Food Hypersensitivity
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).463 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!