Diethoxyphosphoryloxy‐oleanolic acid is a nanomolar‐inhibitor of butyrylcholinesterase
Copyright policy )Diethoxyphosphoryloxy‐oleanolic acid is a nanomolar‐inhibitor of butyrylcholinesterase
AbstractA series of new betulin, lupeol, erythrodiol, and oleanolic acid phosphoryloxy‐ and furoyloxy‐derivatives has been synthesized and their structure was confirmed by NMR spectroscopy. Synthesized compounds were subjected to Ellman's assays to determine their ability to inhibit the enzymes AChE and BChE. Among them, diethoxyphosphoryloxy‐oleanolic acid inhibited BChE with a value of 99%, thereby acting as a mixed‐type inhibitor holding very low Ki values of Ki = 6.59 nM and Ki’ = 1.97 nM, respectively.
- Russian Academy of Sciences Russian Federation
- Ufa Institute of Chemistry Russian Federation
- Martin Luther University Halle-Wittenberg Germany
Structure-Activity Relationship, Butyrylcholinesterase, Acetylcholinesterase, Cholinesterase Inhibitors, Oleanolic Acid, Triterpenes
Structure-Activity Relationship, Butyrylcholinesterase, Acetylcholinesterase, Cholinesterase Inhibitors, Oleanolic Acid, Triterpenes
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