The hypocretins/orexins: integrators of multiple physiological functions
Copyright policy )The hypocretins/orexins: integrators of multiple physiological functions
The hypocretins (Hcrts), also known as orexins, are two peptides derived from a single precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin system has been associated with numerous physiological functions, including sleep/arousal, energy homeostasis, endocrine, visceral functions and pathological states, such as narcolepsy and drug abuse. Here, we review the discovery of Hcrt/orexins and their receptors and propose a hypothesis as to how the orexin system orchestrates these multifaceted physiological functions.Linked ArticlesThis article is part of a themed section on Orexin Receptors. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐2
- Stanford University United States
- Third Military Medical University China (People's Republic of)
Orexins, Neuropeptides, Intracellular Signaling Peptides and Proteins, Sensation, Cognition, Reward, Orexin Receptors, Animals, Humans, Arousal, Energy Metabolism, Sleep, Locomotion, Stress, Psychological
Orexins, Neuropeptides, Intracellular Signaling Peptides and Proteins, Sensation, Cognition, Reward, Orexin Receptors, Animals, Humans, Arousal, Energy Metabolism, Sleep, Locomotion, Stress, Psychological
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