Glycosaminoglycan and versican deposits in taxane-induced sclerosis

descriptionPublicationkeyboard_double_arrow_right Article 17 Aug 2015 English Publisher:Oxford University Press (OUP)Journal:British Journal of Dermatology, volume 173, pages 1,054-1,058 (issn: 0007-0963,

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Authors: K. Okada; Y. Endo; Y. Miyachi; Y. Koike; Y. Kuwatsuka; A. Utani;

doi: 10.1111/bjd.13899

pmid: 25973640

Glycosaminoglycan and versican deposits in taxane-induced sclerosis

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Abstract

Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available. Here, we report a case of generalized scleroderma and a case of early-stage oedematous sclerosis, both of which presented with intense versican deposits after administration of taxane for angiosarcoma.

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Keywords

Male, Scalp, Sclerosis, Skin Neoplasms, Hemangiosarcoma, Docetaxel, Middle Aged, Scleroderma, Localized, Versicans, Head and Neck Neoplasms, Humans, Taxoids, Glycosaminoglycans

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