patients when restricted to those with baseline viral loads >9 log10 copies/mL. Second, our study focused on a real-life treatment setting; this is in contrast to a clinical trial, in which treatment protocols are followed much more rigorously and higher response rates are expected. Finally, we agree that the number of patients in Figure 2 was low. However, this was only used as a supplement to the main results (Figure 1 and Table 3), which were based on greater numbers of patients.