The association and prognostic relevance of cancerous inhibitor of protein phosphatase 2A and inflammation in tongue squamous cell carcinoma
Copyright policy )The association and prognostic relevance of cancerous inhibitor of protein phosphatase 2A and inflammation in tongue squamous cell carcinoma
Cancerous inhibitor of protein phosphatase 2A ( CIP 2A) prevents proteolytic degradation of a universal transcription factor, c‐Myc. Strong CIP 2A expression associates with poor prognosis in early‐stage tongue cancer and in other cancers. The aim of this study was to evaluate CIP 2A and mucosal inflammation in tongue hyperplasia, in tongue cancer, and in its metastasis. Retrospective tongue and lymph node specimens (n = 105) were stained immunohistochemically with polyclonal antibody anti‐ CIP 2A. CIP 2A staining intensity and inflammation were assessed semi‐quantitatively with light microscopy. CIP 2A was similarly detected in tongue cancer and tongue hyperplasia, whereas local inflammation was stronger in cancer (p = 0.000). CIP 2A expression was increased in metastasized cancer compared to non‐metastasized (p = 0.019). Markers for poorer survival were tumor size of ≥20 mm, presence of metastasis and nodal CIP 2A (p = 0.031, p = 0.000, p = 0.042). Cancer patients aged ≥60 with increased inflammation predicted poor survival (p = 0.037). CIP 2A and inflammation might play a role in progression of tongue cancer.
- University of Helsinki Finland
- Helsinki University Hospital Finland
- Tampere University Hospital Finland
- Tampere University Finland
- RMIT University Australia
Adult, Aged, 80 and over, Inflammation, Male, Hyperplasia, Adolescent, Staining and Labeling, Intracellular Signaling Peptides and Proteins, Mouth Mucosa, Membrane Proteins, Middle Aged, Prognosis, Autoantigens, Tongue, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Female, Aged, Retrospective Studies
Adult, Aged, 80 and over, Inflammation, Male, Hyperplasia, Adolescent, Staining and Labeling, Intracellular Signaling Peptides and Proteins, Mouth Mucosa, Membrane Proteins, Middle Aged, Prognosis, Autoantigens, Tongue, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Female, Aged, Retrospective Studies
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