Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis

descriptionPublicationkeyboard_double_arrow_right Article 20 Jul 2017 English Publisher:WileyJournal:Allergy, volume 73, pages 29-36 (issn: 0105-4538, eissn: 1398-9995,

Copyright policy )

Authors: M. Furue; K. Yamamura; M. Kido‐Nakahara; T. Nakahara; Y. Fukui;

doi: 10.1111/all.13239

pmid: 28670717

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis

- Summary
- Subjects
- Metrics

Abstract

AbstractAtopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)‐deviated immune reactions. Interleukin‐31 (IL‐31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti‐IL‐31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL‐31 and its receptor with special references to atopic itch.

Related Organizations

Kyushu University
Japan
Kyushu University Hospital
Japan

Keywords

Basic Helix-Loop-Helix Proteins, Interleukins, Pruritus, Disease Management, Receptors, Interleukin, Dermatitis, Atopic, Structure-Activity Relationship, Gene Expression Regulation, Cytokines, Humans, Endothelial PAS Domain-Containing Protein 1, Inflammation Mediators, Biomarkers

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	206
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%