Post-thrombotic syndrome (PTS) arises from venous outflow restriction.1,2 It may occur in 20-50% of patients after a deep vein thrombosis (DVT) and is characterized by edema, skin changes, pruritis, paresthesias, and pain, which can adversely affect quality of life (QOL).1,2 Adequate dosing and duration of anticoagulation for DVTs may lower the likelihood of PTS;3 however, compression therapy has also been used for prevention and treatment.4-6 While this therapy, which includes bandaging or compression stockings, has been proposed to reduce edema and improve QOL,6,7 clinicians, articles, and guidelines differ in their recommendations concerning the use of these devices for prevention and treatment of PTS.1-6 This article discusses two Cochrane reviews evaluating prevention and treatment of PTS.5,8.