AbstractBackgroundIn the area of oncology, molecular imaging techniques are becoming increasingly utilised. In neuro‐oncology imaging, 18Fluoro‐O‐(2) fluoroethyl‐L‐tyrosine (18F‐FET) is one of the molecular tracers used in positron‐emission tomography (PET). Here, we investigated the correlation between maximum standard uptake value (SUV) of 18F‐FET PET and histologically determined World Health Organization (WHO) grade in glioma.Patients and MethodsThis was a retrospective review of all 18F‐FET PET studies conducted between August 2014 and August 2019. Review was conducted to identify imaging studies performed on patients who had a glioma with histopathology results from surgical resection or biopsy available.ResultsA total of 31 18F‐FET PET studies of histologically confirmed glioma were included. WHO grades ranged from II‐IV. A positive correlation between maximum SUV uptake on 18F‐FET PET and WHO grade was observed.ConclusionsThere was a correlation identified between WHO glioma grade and maximum SUV on 18F‐FET PET. Further studies are recommended to explore this relationship.